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Abstract
Grant Number: 1R01OH007495-01A1 Project Title: Genetic/Exposure Interaction in Beryllium Disease
PI Information: Name Title ROSENMAN, KENNETH D. rosenman@msu.edu Abstract: DESCRIPTION (provided by applicant): A cohort of 1,517 former beryllium workers from two facilities in Eastern Pennsylvania has had medical testing and characterization of their exposure. Medical testing has consisted of blood lymphocyte proliferative transformation (LPT), spirometry and a chest x-ray interpreted by a panel of three "B" readers. Beryllium sensitization has been confirmed by a second positive LPT and chronic beryllium disease by lung biopsy and LPT testing of lavage fluid. As part of the medical testing, which has already been performed, whole blood was collected and frozen and a separate consent form to allow for future genetic testing was obtained from participants. Coincidental with the medical testing a detailed exposure assessment for each participant was constructed using all previous air sampling data, review of process and engineering changes over time and interviews with long term workers. Using a 3 to 1 case-control match this proposal will fund genetic testing of individuals with either beryllium sensitization or chronic beryllium disease. This proposal will allow study of the genetic/exposure interaction of a large well characterized group of individuals who all had beryllium exposure and who have a high rate of beryllium sensitization or chronic disease yet only 11.0% of the cohort has developed these changes. The results of this study will help to elucidate the underlying mechanism of beryllium sensitization and chronic disease.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
berylliosis, beryllium, environmental exposure, gene environment interaction, gene interaction, occupational health /safety
biomarker, genetic marker, genetic screening, genetic susceptibility, leukocyte activation /transformation, occupational hazard
clinical research, human subject, nucleic acid sequence, pneumoradiography, polymerase chain reaction, spirometry
Institution: MICHIGAN STATE UNIVERSITY 301 Administration Bldg EAST LANSING, MI 48824 Fiscal Year: 2003 Department: MEDICINE Project Start: 01-AUG-2003 Project End: 31-JUL-2006 ICD: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH IRG: SOH